Reminder- Notice Regarding the Detection of the Bronchodilator Drug Clenbuterol

15 March 2023
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Trainers are reminded that the International Screening Limit (ISL) for clenbuterol of 0.1ng/ml in urine has beenadopted by Harness Racing    Australia (HRA) and will be implemented by Australian racing laboratories witheffect from 1 April 2023.

This will have important implications for the detection of clenbuterol following its administration to  racehorses and will lead to a prolongation of detection times for this substance.

The European Horserace Scientific Liaison Committee (EHSLC) has published detection time information forclenbuterol following both oral and nebulised administration. The published detection times of 13 days (oral)and 6 days (nebulised), for the stated dosage regimen and pharmaceutical preparations, are valid for the new ISL to be applied by Australian racing laboratories.

The EHSLC detection time document can be found here.

It should be noted that the revised detection times for clenbuterol are longer than the 3 - 4 days (oral) and 2 days (nebulised) previously reported, using the analytical methodology at that time, in the Australian EquineVeterinary Association (now Equine Veterinarians Australia - EVA) publication ‘Detection of TherapeuticSubstances in Racing Horses’ (‘The White Book’).

Veterinarians are therefore advised that recommended withdrawal periods for treatment with clenbuterol (forexample, in products including, but not limited to, Airway Gel, Claire Gel, Broncopulmin Powder, VentipulminGranules, Ventipulmin Injection and products in combination with trimethoprim and sulfadiazine) must bebased on the published EHSLC detection times and not on previous advice provided in the ‘The White Book’,and that trainers are warned accordingly.

The EHSLC detection times appear, alongside those previously published in ‘The White Book’, in the currentEquine Veterinarians Australia (EVA) publication ‘Equine Medication Detection and Withdrawal Times: A Survey of Veterinarians in Australia’. 

It is important to note that a withdrawal (or withholding) period is not the same as a detection period.   Anywithdrawal period should be calculated based on the published detection time, with the addition of a suitablesafety margin based on the circumstances of the administration, including dose, route of administration andpreparation administered.

It should also be noted that none of the veterinary preparations containing clenbuterol registered for use in Australia are registered for administration by nebulisation. Such administration would therefore representsoff-label use of these products.

The screening limit of 0.1ng/mL in urine for clenbuterol will come into effect on

1 April, 2023.

If anyone requires further information please contact HRNSW Integrity Department on 9722 6600.

 

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